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Article

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.

The Journal of biological chemistry - 10 Feb 2006

Seo Dong-Wan, Li Hongmei, Qu Cheng-Kui, Oh Junseo, Kim Young-Sik, Diaz Tere, Wei Beiyang, Han Jeung-Whan, Stetler-Stevenson William G

Abstract excerpt

The tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity required for cell migration/invasion associated with cancer progression and angiogenesis. TIMPs also modulate cell proliferation in vitro and angiogenesis in vivo independent of their matrix metalloproteinase inhibitory activity. Here, we show that TIMP-2 mediates G1 growth arrest in human endothelial cells through de...

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Identifiers

PMID: 16326706
DOI: 10.1074/jbc.M509932200
PMCID: PMC1361361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.PMID 16326706Read ↗

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