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Article

P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3

1 Mar 2012

Abstract excerpt

Malignant gliomas are the most common and the most lethal primary brain tumors in adults. Among malignant gliomas, 60%-80% show loss of P14ARF tumor suppressor activity due to somatic alterations of the INK4A/ARF genetic locus. The tumor suppressor activity of P14ARF is in part a result of its ability to prevent the degradation of P53 by binding to and sequestering HDM2. However, the subsequent finding of P14ARF...

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PMID: 22378045
DOI: 10.1172/jci38596

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