Article
Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway.
Blood - 6 Dec 2012
Kim Soo Hyeon, Cho Young-Rak, Kim Hyeon-Ju, Oh Joa Sub, Ahn Eun-Kyung, Ko Hye-Jin, Hwang Byung Joon, Lee Seo-Jin, Cho Yongwan, Kim Yong Kee, Stetler-Stevenson William G, Seo Dong-Wan
Abstract excerpt
In cancer, VEGF-induced increase in vascular permeability results in increased interstitial pressure, reducing perfusion and increasing hypoxia, which reduce delivery of chemotherapeutic agents and increase resistance to ionizing radiation. Here, we show that both TIMP-2 and Ala + TIMP-2, a TIMP-2 mutant without matrix metalloproteinase inhibitory activity, antagonize the VEGF-A-induced increase in vascular...
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