Article
p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis.
The Journal of cell biology - 7 Jan 2002
Matsumoto Taro, Turesson Ingela, Book Majlis, Gerwins Pär, Claesson-Welsh Lena
Abstract excerpt
The p38 mitogen-activated protein kinase (p38) is activated in response to environmental stress and inflammatory cytokines. Although several growth factors, including fibroblast growth factor (FGF)-2, mediate activation of p38, the consequences for growth factor-dependent cellular functions have not been well defined. We investigated the role of p38 activation in FGF-2-induced angiogenesis. In collagen gel...
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