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Article

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and Metastasis

1 Jan 2008

Abstract excerpt

Tissue inhibitors of metalloproteinases (TIMPs) are classically known for regulating members of the metzincin protease family and are well recognized for their inhibitory effects in cancer development and progression. Despite their common evolutionary structure, the four TIMP proteins have unique properties and regulation, and produce distinct phenotypes when ablated. A comprehensive assessment of their function...

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PMID: 18568853
DOI: 10.1080/10408360801973244

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