Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.

doi:10.1006/bbrc.1997.8059

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Article

Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.

Biochemical and biophysical research communications - 4 Feb 1998

Fantz C R, Shaw D, Moore J G, Spencer H T

Abstract excerpt

Retroviral gene transfer of dominant selectable markers into hematopoietic cells can be used to select genetically modified cells in vivo or to attenuate the toxic effects of chemotherapeutic agents. We show that retroviral gene transfer of thymidylate synthase (TS) confers resistance to TS direc...

Topics

Animals
Cell Line
Drug Resistance
Floxuridine
Folic Acid Antagonists
Gene Expression
Genetic Variation
Genetic Vectors
Harvey murine sarcoma virus
Humans
Mice
Proviruses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Tetrahydrofolate Dehydrogenase

Thymidylate Synthase

Transduction, Genetic

Transfection

Trimetrexate

Source

Open in PubMed

Identifiers

PMID: 9473470
DOI: 10.1006/bbrc.1997.8059

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9473470-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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