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Article

Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.

The Journal of biological chemistry - 17 Jun 2005

Skacel Nancy, Menon Lata G, Mishra Prasunkumar J, Peters Rowayda, Banerjee Debabrata, Bertino Joseph R, Abali Emine Ercikan

Abstract excerpt

Human dihydrofolate reductase (DHFR) protein levels rapidly increase upon exposure to methotrexate, a potent inhibitor of this enzyme. A model to explain this increase proposes that DHFR inhibits its own translation by binding to its cognate mRNA and that methotrexate disrupts the DHFR protein-mRNA complex allowing its translation to resume. In the present study, Chinese hamster ovary cells lacking DHFR were...

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Source

Identifiers

PMID: 15817466
DOI: 10.1074/jbc.M500277200

Genes

DHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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