Article
Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma.
Transfusion - 1 Sept 2005
Brojer E, Zupanska B, Guz K, Orziñska A, Kaliñska A
Abstract excerpt
BACKGROUND: Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS: Plasma DNA was extracted (by manual and/or automatic method) from 255 D- pregnant women and amplified in exons 7 and 10 and intron 4 of RHD...
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