Article
Prediction of fetal D status from maternal plasma: introduction of a new noninvasive fetal RHD genotyping service.
Transfusion - 1 Aug 2002
Finning K M, Martin P G, Soothill P W, Avent N D
Abstract excerpt
BACKGROUND: Invasive procedures to obtain fetal DNA for prenatal blood grouping present a risk to the fetus. During pregnancy, cell-free fetal DNA is present in maternal blood. The detection of RHD sequences in maternal plasma has been used to predict fetal D status, based on the assumption that RHD is absent in D- genomes. STUDY DESIGN AND METHODS: Real-time PCR assays were designed to distinguish RHD from...
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