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Article

Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin.

The Journal of investigative dermatology - 1 Jan 2018

Albibas Amel A, Rose-Zerilli Matthew J J, Lai Chester, Pengelly Reuben J, Lockett Gabrielle A, Theaker Jeffrey, Ennis Sarah, Holloway John W, Healy Eugene

Abstract excerpt

Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches, PIPs), which are considered potential early precursors of skin cancer. Although the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly <3,000 p53 immunopositive cells in size, within normal...

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Source

Identifiers

PMID: 28844940
DOI: 10.1016/j.jid.2017.07.844

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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