Article
[Relationship between GSTT1, GSTM1 and NQO1 gene polymorphism and acute myeloid leukemia and recurrent chromosome translocations].
Zhonghua yi xue za zhi - 31 Aug 2005
Yang Lin, Zhang Yue, Zhang Mei-rong, Xiao Zhi-jian
Abstract excerpt
OBJECTIVE: To investigate the impact of GSTM1, GSTT1 and NQO1 genotypes on susceptibility to acute myeloid leukemia (AML) and recurrent chromosome translocations of AML. METHODS: GSTT1, GSTM1 and NQO1 genotypes were detected in 228 adult patients with de novo AML and 241 controls by PCR or PCR-RFLP. RESULTS: The frequency of GSTM1 null genotype in the AML patients was 62.3%, significantly higher than that in the...
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