Article
[Investigation of GSTT1, GSTM1 and NQO1 genes polymorphisms in myelodysplastic syndromes].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Nov 2005
Yang Lin, Zou Xu, Zhang Mei-rong, Zhang Yue, Hao Yu-shu, Xiao Zhi-jian
Abstract excerpt
OBJECTIVE: To investigate the relationship between GSTM1, GSTT1 and NQO1(C609T) genotypes and myelodysplastic syndromes (MDS) susceptibility and chromosome abnormalities. METHODS: GSTT1, GSTM1 and NQO1(C609T) genotypes were detected in 52 MDS patients and 241 unrelated controls by PCR or PCR-RFLP. RESULTS: The incidence of GSTT1 and GSTM1 null genotype was significantly increased in MDS patients as compared with...
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