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Article

Assessing the impact of population stratification on genetic association studies.

Nature genetics - 1 Apr 2004

Freedman Matthew L, Reich David, Penney Kathryn L, McDonald Gavin J, Mignault Andre A, Patterson Nick, Gabriel Stacey B, Topol Eric J, Smoller Jordan W, Pato Carlos N, Pato Michele T, Petryshen Tracey L, Kolonel Laurence N, Lander Eric S, Sklar Pamela, Henderson Brian, Hirschhorn Joel N, Altshuler David

Abstract excerpt

Population stratification refers to differences in allele frequencies between cases and controls due to systematic differences in ancestry rather than association of genes with disease. It has been proposed that false positive associations due to stratification can be controlled by genotyping a few dozen unlinked genetic markers. To assess stratification empirically, we analyzed data from 11 case-control and...

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PMID: 15052270
DOI: 10.1038/ng1333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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