Article
Molecular analysis of inflammatory markers in trauma patients at risk of postinjury complications.
The Journal of trauma - 1 Jul 2007
McDaniel D Olga, Hamilton James, Brock Marjolyn, May Warren, Calcote Lynn, Tee Lee Y, Vick Laura, Newman D Brian, Vick Kenneth, Harrison Sebron, Timberlake Gregory, Toevs Christine
Abstract excerpt
BACKGROUND: Genetic differences associated with individual's immune responses appear to be a major contributing factor to the development of trauma- induced sepsis. Thus, effective treatment of sepsis requires the identification of the patients who are at increased risk for sepsis. METHODS: Sixty-eight patients, of which the majority had an injury severity score >15, and 118 controls from the same geographic...
Topics
- Black or African American
- Cytokines
- Gene Frequency
- Genotype
- Humans
- Injury Severity Score
- Male
- Patient Selection
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Sepsis
- Toll-Like Receptor 2
- Toll-Like Receptor 4