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Article

Contribution of APOE Genetic Variants to Dyslipidemia

13 Apr 2023

Abstract excerpt

Background: apo (apolipoprotein) E has crucial role in lipid metabolism. The genetic variation in APOE gene is associated with monogenic disorders and contributes to polygenic hypercholesterolemia and to interindividual variability in cholesterol. APOE rare variants may be involved in the phenotype of genetic hyperlipidemias. Methods: Exon 4 of APOE were sequenced in all consecutive unrelated subjects with...

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PMID: 37051929
DOI: 10.1161/atvbaha.123.318977

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