Article
APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups.
Lipids in health and disease - 21 Sept 2021
Goyal Shiwali, Tanigawa Yosuke, Zhang Weihua, Chai Jin-Fang, Almeida Marcio, Sim Xueling, Lerner Megan, Chainakul Juliane, Ramiu Jonathan Garcia, Seraphin Chanel, Apple Blair, Vaughan April, Muniu James, Peralta Juan, Lehman Donna M, Ralhan Sarju, Wander Gurpreet S, Singh Jai Rup, Mehra Narinder K, Sidorov Evgeny, Peyton Marvin D, Blackett Piers R, Curran Joanne E, Tai E Shyong, van Dam Rob, Cheng Ching-Yu, Duggirala Ravindranath, Blangero John, Chambers John C, Sabanayagam Charumathi, Kooner Jaspal S, Rivas Manuel A, Aston Christopher E, Sanghera Dharambir K
Abstract excerpt
BACKGROUND: Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally...
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