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Article

Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis.

International journal of molecular sciences - 27 Mar 2021

Lin Chia-Hung, Liao Chen-Chung, Chen Mei-Yu, Chou Teh-Ying

Abstract excerpt

Protein O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine (GlcNAc) to the hydroxyl groups of Ser/Thr residues on numerous nucleocytoplasmic proteins. Two enzymes are responsible for O-GlcNAc cycling on substrate proteins: O-GlcNAc transferase (OGT) catalyzes the addition while O-GlcNAcase (OGA) helps the removal of GlcNAc. O-GlcNAcylation modifies protein...

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PMID: 33801653
DOI: 10.3390/ijms22073463
PMCID: PMC8037101

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