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Article

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder.

Cell reports - 26 Nov 2024

Matheny-Rabun Courtney, Mokashi Sneha S, Radenkovic Silvia, Wiggins Kali, Dukes-Rimsky Lynn, Angel Peggi, Ghesquiere Bart, Kozicz Tamas, Steet Richard, Morava Eva, Flanagan-Steet Heather

Abstract excerpt

Core components of the N-glycosylation pathway are known, but the metabolic and post-translational mechanisms regulating this pathway in normal and disease states remain elusive. Using a multi-omic approach in zebrafish, we discovered a mechanism whereby O-GlcNAcylation directly impacts the expression and abundance of two rate-limiting proteins in the N-linked glycosylation pathway. We show in a model of an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39561044
DOI: 10.1016/j.celrep.2024.114976
PMCID: PMC11656453

Genes

PMM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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