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Article

Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.

Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006

Forsythe Michele E, Love Dona C, Lazarus Brooke D, Kim Eun Ju, Prinz William A, Ashwell Gilbert, Krause Michael W, Hanover John A

Abstract excerpt

A dynamic cycle of O-linked N-acetylglucosamine (O-GlcNAc) addition and removal acts on nuclear pore proteins, transcription factors, and kinases to modulate cellular signaling cascades. Two highly conserved enzymes (O-GlcNAc transferase and O-GlcNAcase) catalyze the final steps in this nutrient-driven "hexosamine-signaling pathway." A single nucleotide polymorphism in the human O-GlcNAcase gene is linked to type...

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Identifiers

PMID: 16882729
DOI: 10.1073/pnas.0601931103
PMCID: PMC1567679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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