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Article

A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.

Biophysical journal - 1 Jan 2005

Chang Hsueh-Kai, Yeh Shih-Hao, Shieh Ru-Chi

Abstract excerpt

The glutamate at site 224 of a Kir2.1 channel plays an important role in K+ permeation. The single-channel inward current flickers with reduced conductance in an E224G mutant. We show that open-channel fluctuations can also be observed in E224C, E224K, and E224Q mutants. Yet, open-channel fluctua...

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Identifiers

PMID: 15516518
DOI: 10.1529/biophysj.104.052217
PMCID: PMC1305002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15516518-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.PMID 15516518Read ↗

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