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Article

Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block.

The Journal of general physiology - 1 Feb 2008

Carvacho Ingrid, Gonzalez Wendy, Torres Yolima P, Brauchi Sebastian, Alvarez Osvaldo, Gonzalez-Nilo Fernando D, Latorre Ramon

Abstract excerpt

The internal vestibule of large-conductance Ca(2+) voltage-activated K(+) (BK) channels contains a ring of eight negative charges not present in K(+) channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel conductance through an electrostatic mechanism (Brelidze, T.I., X. Niu, and K.L. Magleby. 2003. Proc. Natl. Acad. Sci. USA. 100:9017-9022). In BK channels there are also two acidic...

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Identifiers

PMID: 18227273
DOI: 10.1085/jgp.200709862
PMCID: PMC2213566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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