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Article

Hairy is a cell context signal controlling Notch activity.

Development, growth & differentiation - 1 Dec 2005

Cui Yanzhen

Abstract excerpt

Notch signaling regulates cell fate determination and many developmental processes. Here we report that lateral inhibition, a major mechanism for Notch activity, is modulated by Hairy, a bHLH-WRPW protein. In Xenopus, Notch can have from inhibitory, permissive to enhancing roles in muscle or neural differentiation. These cell context-dependent effects correlate with Hairy expression levels from high to low,...

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Identifiers

PMID: 16316406
DOI: 10.1111/j.1440-169X.2005.00823.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Hairy is a cell context signal controlling Notch activity.PMID 16316406Read ↗

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Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

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Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Semantic proximity Read ↗

Hairy transcriptional repression targets and cofactor recruitment in Drosophila.Semantic proximity Read ↗

Two modes of action by which Xenopus hairy2b establishes tissue demarcation in the Spemann-Mangold organizer.Semantic proximity Read ↗

The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea.Semantic proximity Read ↗

Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.Semantic proximity Read ↗

Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression.Semantic proximity Read ↗

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