Article
In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.
The EMBO journal - 16 Dec 1996
Jiménez G, Pinchin S M, Ish-Horowicz D
Abstract excerpt
The Hairy and Runt pair-rule proteins regulate Drosophila segmentation by repressing transcription. To explore the ability of these proteins to function as promoter-bound regulators in vivo, we examined the effects of Hairy and Runt derivatives containing heterologous transcriptional activation domains (HairyAct and RunAct). Using this approach, we find that Hairy and Runt efficiently target such activation...
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