Article
Comparative genomics analysis of human sequence variation in the UGT1A gene cluster.
The pharmacogenomics journal - 1 Jan 2000
Maitland M L, Grimsley C, Kuttab-Boulos H, Witonsky D, Kasza K E, Yang L, Roe B A, Di Rienzo A
Abstract excerpt
Common polymorphisms within the human UGT1A gene locus are associated with irinotecan and tranilast toxicity. To uncover additional functional variation across this gene cluster, cross-species sequence comparisons were performed. Evolutionarily conserved segments (a total of 47.1 kb) were re-sequenced in 24 African-American, 24 European-American, and 24 Asian individuals, and 381 segregating sites (including 123...
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