Article
Comparison of Eight Technologies to Determine Genotype at the UGT1A1 (TA)n Repeat Polymorphism: Potential Clinical Consequences of Genotyping Errors?
International journal of molecular sciences - 30 Jan 2020
Sissung Tristan M, Barbier Roberto H, Price Douglas K, Plona Teri M, Pike Kristen M, Mellott Stephanie D, Baugher Ryan N, Whiteley Gordon R, Soppet Daniel R, Venzon David, Berman Arlene, Rajan Arun, Giaccone Giuseppe, Meltzer Paul, Figg William D
Abstract excerpt
To ensure accuracy of UGT1A1 (TA)n (rs3064744) genotyping for use in pharmacogenomics-based irinotecan dosing, we tested the concordance of several commonly used genotyping technologies. Heuristic genotype groupings and principal component analysis demonstrated concordance for Illumina sequencing, fragment analysis, and fluorescent PCR. However, Illumina sequencing and fragment analysis returned a range of...
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