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Article

The schizophrenic faces of PICK1.

Trends in pharmacological sciences - 1 Nov 2006

Dev Kumlesh K, Henley Jeremy M

Abstract excerpt

Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we...

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Source

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Identifiers

PMID: 17011050
DOI: 10.1016/j.tips.2006.09.007
PMCID: PMC3314511

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The schizophrenic faces of PICK1.PMID 17011050Read ↗

PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population.Semantic proximity Read ↗

Association study of PICK1 rs3952 polymorphism and schizophrenia.Semantic proximity Read ↗

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia.Semantic proximity Read ↗

Serine racemase binds to PICK1: potential relevance to schizophrenia.Semantic proximity Read ↗

The binding affinities of proteins interacting with the PDZ domain of PICK1.Semantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.Semantic proximity Read ↗

Expression of GSK3β, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patientsSemantic proximity Read ↗

Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis.Semantic proximity Read ↗

[Niemann-Pick type C disease and psychosis: Two siblings].Semantic proximity Read ↗

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.Semantic proximity Read ↗

Modeling schizophrenia in flies.Semantic proximity Read ↗

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