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Article

Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit.

Developmental cell - 1 Aug 2001

Rottbauer W, Baker K, Wo Z G, Mohideen M A, Cantiello H F, Fishman M C

Abstract excerpt

The heart must function from the moment of its embryonic assembly, but the molecular underpinnings of the first heart beat are not known, nor whether function determines form at this early stage. Here, we find by positional cloning that the embryonic lethal island beat (isl) mutation in zebrafish disrupts the alpha1 C L-type calcium channel subunit (C-LTCC). The isl atrium is relatively normal in size, and...

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Identifiers

PMID: 11702785
DOI: 10.1016/s1534-5807(01)00023-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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