Article
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005
Li Ming, Phatnani Hemali P, Guan Ziqiang, Sage Harvey, Greenleaf Arno L, Zhou Pei
Abstract excerpt
The phosphorylation state of the C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase II changes as polymerase transcribes a gene, and the distinct forms of the phospho-CTD (PCTD) recruit different nuclear factors to elongating polymerase. The Set2 histone methyltransferase from yeast was recently shown to bind the PCTD of elongating RNA polymerase II by means of a novel domain termed the...
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