Article
Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II.
Molecular cell - 21 Jan 2016
Suh Hyunsuk, Ficarro Scott B, Kang Un-Beom, Chun Yujin, Marto Jarrod A, Buratowski Stephen
Abstract excerpt
Dynamic interactions between RNA polymerase II and various mRNA-processing and chromatin-modifying enzymes are mediated by the changing phosphorylation pattern on the C-terminal domain (CTD) of polymerase subunit Rpb1 during different stages of transcription. Phosphorylations within the repetitive heptamer sequence (YSPTSPS) of CTD have primarily been defined using antibodies, but these do not distinguish...
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