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Article

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.

PLoS genetics - 1 Jul 2012

Qu Meng, Yang Bing, Tao Li, Yates John R, Russell Paul, Dong Meng-Qiu, Du Li-Lin

Abstract excerpt

In response to DNA damage, the eukaryotic genome surveillance system activates a checkpoint kinase cascade. In the fission yeast Schizosaccharomyces pombe, checkpoint protein Crb2 is essential for DNA damage-induced activation of downstream effector kinase Chk1. The mechanism by which Crb2 mediates Chk1 activation is unknown. Here, we show that Crb2 recruits Chk1 to double-strand breaks (DSBs) through a direct...

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Source

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Identifiers

PMID: 22792081
DOI: 10.1371/journal.pgen.1002817
PMCID: PMC3390401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.PMID 22792081Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Regulation of checkpoint kinases through dynamic interaction with Crb2.Semantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.Semantic proximity Read ↗

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Semantic proximity Read ↗

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Semantic proximity Read ↗

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