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Article

Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.

Genes & development - 1 Aug 2008

Kilkenny Mairi L, Doré Andrew S, Roe S Mark, Nestoras Konstantinos, Ho Jenny C Y, Watts Felicity Z, Pearl Laurence H

Abstract excerpt

Schizosaccharomyces pombe Crb2 is a checkpoint mediator required for the cellular response to DNA damage. Like human 53BP1 and Saccharomyces cerevisiae Rad9 it contains Tudor(2) and BRCT(2) domains. Crb2-Tudor(2) domain interacts with methylated H4K20 and is required for recruitment to DNA dsDNA breaks. The BRCT(2) domain is required for dimerization, but its precise role in DNA damage repair and checkpoint...

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PMID: 18676809
DOI: 10.1101/gad.472808
PMCID: PMC2492745

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Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.PMID 18676809Read ↗

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.Semantic proximity Read ↗

Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.Semantic proximity Read ↗

Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint.Semantic proximity Read ↗

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.Semantic proximity Read ↗

Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Semantic proximity Read ↗

Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.Semantic proximity Read ↗

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.Semantic proximity Read ↗

The fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Semantic proximity Read ↗

BRCT domains: phosphopeptide binding and signaling modules.Semantic proximity Read ↗

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