Article

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production

2020-02-18

Abstract excerpt

<h4>ABSTRACT</h4> Carnosine and related β-alanine-containing peptides are believed to be important antioxidants, pH-buffers and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This study describes the first animal model lacking the enzyme glutamic acid decarboxylase-like 1 (GADL1). We show that Gadl1 -/- mice are deficient in β-alanine, carnosine and anserin...

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Literature Corpus work: 826e7efe-8932-525f-a725-7b10f086dd78
DOI: 10.1101/2020.02.18.954438

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