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Article

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.

The EMBO journal - 1 Jul 1997

Peghini P, Janzen J, Stoffel W

Abstract excerpt

Four L-glutamate neurotransmitter transporters, the three Na(+)-dependent GLAST-1, GLT-1 and EAAC-1, and the Cl(-)-dependent EAAT-4, form a new family of structurally related integral plasma membrane proteins with different distribution in the central nervous system. They may have pivotal functions in the regulation of synaptic L-glutamate concentration during neurotransmission and are believed to prevent...

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Identifiers

PMID: 9233792
DOI: 10.1093/emboj/16.13.3822
PMCID: PMC1170006

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