Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.

doi:10.1093/emboj/16.13.3822

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Article

Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.

The EMBO journal - 1 Jul 1997

Peghini P, Janzen J, Stoffel W

Abstract excerpt

Four L-glutamate neurotransmitter transporters, the three Na(+)-dependent GLAST-1, GLT-1 and EAAC-1, and the Cl(-)-dependent EAAT-4, form a new family of structurally related integral plasma membrane proteins with different distribution in the central nervous system. They may have pivotal functio...

Topics

Amino Acid Sequence
Amino Acid Transport System X-AG
Amino Acids, Dicarboxylic
Animals
Brain
Carrier Proteins
Epilepsy
Excitatory Amino Acid Transporter 1
Female
Gene Targeting
Glutamate Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamic Acid

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Motor Activity

Pentylenetetrazole

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9233792
DOI: 10.1093/emboj/16.13.3822
PMCID: PMC1170006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9233792-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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