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Article

Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.

Brain research - 9 Aug 2005

Xie Xinmin, Dumas Theodore, Tang Lamont, Brennan Thomas, Reeder Thadd, Thomas Winston, Klein Robert D, Flores Judith, O'Hara Bruce F, Heller H Craig, Franken Paul

Abstract excerpt

The Na(+)-independent alanine-serine-cysteine transporter 1 (Asc-1) is exclusively expressed in neuronal structures throughout the central nervous system (CNS). Asc-1 transports small neutral amino acids with high affinity especially for D-serine and glycine (K(i): 8-12 microM), two endogenous glutamate co-agonists that activate N-methyl-D-aspartate (NMDA) receptors through interacting with the...

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Identifiers

PMID: 16026768
DOI: 10.1016/j.brainres.2005.06.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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