Article
Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.
Brain research - 9 Aug 2005
Xie Xinmin, Dumas Theodore, Tang Lamont, Brennan Thomas, Reeder Thadd, Thomas Winston, Klein Robert D, Flores Judith, O'Hara Bruce F, Heller H Craig, Franken Paul
Abstract excerpt
The Na(+)-independent alanine-serine-cysteine transporter 1 (Asc-1) is exclusively expressed in neuronal structures throughout the central nervous system (CNS). Asc-1 transports small neutral amino acids with high affinity especially for D-serine and glycine (K(i): 8-12 microM), two endogenous glutamate co-agonists that activate N-methyl-D-aspartate (NMDA) receptors through interacting with the...
Topics
- Amino Acid Transport System y+
- Animals
- Animals, Newborn
- Behavior, Animal
- Cloning, Molecular
- Death
- Dose-Response Relationship, Radiation
- Electric Stimulation
- Electroencephalography
- Electromyography
- Evoked Potentials
- Excitatory Postsynaptic Potentials