Article
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.
Cell death and differentiation - 1 Jul 2006
Fujimoto H, Onishi N, Kato N, Takekawa M, Xu X Z, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y
Abstract excerpt
The antioncogenic Chk2 kinase plays a crucial role in DNA damage-induced cell-cycle checkpoint regulation. Here we show that Chk2 associates with the oncogenic protein Wip1 (wild-type p53-inducible phosphatase 1) (PPM1D), a p53-inducible protein phosphatase. Phosphorylation of Chk2 at threonine68 (Thr68), a critical event for Chk2 activation, which is normally induced by DNA damage or overexpression of Chk2, is...
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