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Article

Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993

Sun Y, Nakamura K, Wendel E, Colburn N

Abstract excerpt

We recently reported the detection of a heterozygous G-->C point mutation at codon 280 of p53 in nasopharyngeal carcinoma, which causes an Arg-->Thr substitution. To test whether this mutant p53 has gained function as an oncogene, we overexpressed the mutant p53 in nontumorigenic cells of two model systems: (i) human Saos-2 cells lacking endogenous p53 and (ii) mouse JB6 variants that bear endogenous wild-type...

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Identifiers

PMID: 8464896
DOI: 10.1073/pnas.90.7.2827
PMCID: PMC46189

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