Advances in understanding the roles of TP53 mutations in pancreatic and hepatobiliary cancers.

doi:10.1016/j.jbior.2026.101169

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Article

Advances in understanding the roles of TP53 mutations in pancreatic and hepatobiliary cancers.

Advances in biological regulation - 1 Aug 2026

McCubrey James A, Follo Matilde Y, Ratti Stefano, Manzoli Lucia, Cocco Lucio, Cervello Melchiorre, Augello Giuseppa

Abstract excerpt

TP53 is frequently mutated in various cancers, including pancreatic, hepatocellular, and biliary cancers. These mutations are often associated with poor patient survival and resistance to therapy. In this review, we focus on the progress made in elucidating the effects of TP53 on these cancers. Mutations in these three cancer types were chosen to review as they are related in their origins and to components of...

Topics

Humans
Tumor Suppressor Protein p53
Mutation
Pancreatic Neoplasms
Liver Neoplasms
Biliary Tract Neoplasms
Animals
Carcinoma, Hepatocellular

Source

Open in PubMed

Identifiers

PMID: 42155944
DOI: 10.1016/j.jbior.2026.101169

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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