Article
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression.
Nature - 16 Jul 1992
Laurence J, Hodtsev A S, Posnett D N
Abstract excerpt
In the pathogenesis of AIDS it is not yet understood whether the small fraction of CD4+ T cells (approximately 1%) infected with the human immunodeficiency virus (HIV) are randomly targeted or not. Here we present evidence that human CD4 T-cell lines expressing selected T-cell antigen receptor V beta gene products can all be infected in vitro with HIV-1, but give markedly different titres of HIV-1 virion...
Topics
- Antigen-Presenting Cells
- Antigens, CD
- CD4 Antigens
- CD8 Antigens
- Cell Line
- Genes, gag
- HIV-1
- HLA-D Antigens
- Humans
- Interleukin-2
- Kinetics
- Lymphocyte Depletion