Article
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V beta expression.
Nature - 16 Jul 1992
Laurence J, Hodtsev A S, Posnett D N
Abstract excerpt
In the pathogenesis of AIDS it is not yet understood whether the small fraction of CD4+ T cells (approximately 1%) infected with the human immunodeficiency virus (HIV) are randomly targeted or not. Here we present evidence that human CD4 T-cell lines expressing selected T-cell antigen receptor V beta gene products can all be infected in vitro with HIV-1, but give markedly different titres of HIV-1 virion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.