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Article

A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice.

Science (New York, N.Y.) - 19 Apr 1991

Hügin A W, Vacchio M S, Morse H C

Abstract excerpt

The development of an immunodeficiency syndrome of mice caused by a replication-defective murine leukemia virus (MuLV) is paradoxically associated with a rapid activation and proliferation of CD4+ T cells that are dependent on the presence of B cells. The responses of normal spleen cells to B cell lines that express the defective virus indicated that these lines express a cell surface determinant that shares...

Topics

Animals
Antigens, Viral
B-Lymphocytes
Gene Products, gag
HIV-1
Histocompatibility Antigens Class II
Leukemia Virus, Murine
Lymphocyte Activation
Mice
Mice, Inbred CBA
Murine Acquired Immunodeficiency Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Antigen, T-Cell

T-Lymphocytes

T-Lymphocytes, Helper-Inducer

Virus Replication

Source

Identifiers

PMID: 1850169
DOI: 10.1126/science.1850169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850169-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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