Article
A superantigen interacts with leishmanial infection in antigen-presenting cells to regulate cytokine commitment of responding CD4 T cells.
The Journal of infectious diseases - 15 Oct 2010
Varanasi Vineeth, Mattoo Hamid, Tupperwar Nitin C, Thyagarajan Krishnamurthy, Das Abhishek, Kumar Ramesh, Bal Vineeta, Vaidya Tushar, George Anna, Rath Satyajit
Abstract excerpt
Germ-line retroviral insertions in vertebrate genomes are implicated in the modulation of host immune responses. We demonstrate that CBA/J mice, which carry the proviral integrants mammary tumor virus locus 6 (Mtv6) and mammary tumor virus locus 7 (Mtv7), are less resistant to infection with the protozoan pathogen Leishmania major compared with closely related but Mtv6-negative and Mtv7-negative CBA/CaJ mice....
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