Article
An acutely lethal simian immunodeficiency virus stimulates expansion of V beta 7- and V beta 14-expressing T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 1994
Chen Z W, Kou Z C, Shen L, Regan J D, Lord C I, Halloran M, Lee-Parritz D, Fultz P N, Letvin N L
Abstract excerpt
SIVsmmPBj14, a variant simian immunodeficiency virus isolated from a pig-tailed macaque, stimulates the proliferation of macaque T lymphocytes in vitro and induces an acutely lethal disease in macaques characterized, in part, by lymphadenopathy and splenomegaly. To determine whether SIVsmmPBj14 exhibits superantigen-like activity, in vitro and in vivo studies of T-cell receptor V beta repertoire were undertaken...
Topics
- Acute Disease
- Animals
- Base Sequence
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Lymphocyte Activation
- Macaca nemestrina