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Article

Identification of the B cell superantigen-binding site of HIV-1 gp120

18 Feb 1997

Abstract excerpt

Previous studies showed that the gp120 envelope protein of HIV-1 is able to crosslink membrane IgM on normal human B cells and to induce their activation in a V(H)3 immunoglobulin gene-family-specific manner. Because this V(H) gene family is the largest in the human repertoire, this superantigen (SAg) property is thought to have deleterious consequences for the host, including a progressive decline of B cells...

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Identifiers

PMID: 9037057
DOI: 10.1073/pnas.94.4.1356

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