Article
A lectin-binding, protease-resistant mycobacterial ligand specifically activates V gamma 9+ human gamma delta T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1992
Pfeffer K, Schoel B, Plesnila N, Lipford G B, Kromer S, Deusch K, Wagner H
Abstract excerpt
Bacterial (exogeneous) superantigens have been defined as bifunctional proteinaceous molecules. They bind to class II MHC molecules of presenting cells and engage with particular TCR-V beta gene elements, thereby activating alpha beta T cells in a V beta-oriented fashion. In previous studies we have elucidated that gamma delta T cells exhibit a propensity to vigorously respond toward mycobacterial Ag. Intrigued...
Topics
- Antigens, Bacterial
- Endopeptidases
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Lectins
- Lymphocyte Activation
- Mycobacterium
- Phenotype
- Receptors, Antigen, T-Cell, gamma-delta