Article
CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype.
European journal of immunology - 1 May 2005
Gillespie Geraldine M A, Pinheiro Susana, Sayeid-Al-Jamee Mohammad, Alabi Abraham, Kaye Steve, Sabally Sehu, Sarge-Njie Ramu, Njai Harr, Joof Ken, Jaye Assan, Whittle Hilton, Rowland-Jones Sarah, Dorrell Lucy
Abstract excerpt
The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiretroviral-naive HIV-2- ('HIV-2(+)') and HIV-1-infected ('HIV-1(+)') individuals. Gag-specific...
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