Article
Vanadate triggers the transition from chromosome condensation to decondensation in a mitotic mutant (tsTM13) inactivation of p34cdc2/H1 kinase and dephosphorylation of mitosis-specific histone H3.
European journal of biochemistry - 1 Nov 1996
Ajiro K, Yasuda H, Tsuji H
Abstract excerpt
At the nonpermissive temperature (39 degrees C), chromosomes remain condensed in a temperature-sensitive cell mutant (tsTM13) arrested in the late stage of mitosis. Highly increased activity of histone H1 kinase, hyperphosphorylation of histone H1, and mitosis-specific histone H3 phosphorylation...
Topics
- CDC2 Protein Kinase
- Chromosomes
- Enzyme Inhibitors
- Histones
- Mitosis
- Mutation
- Phosphoprotein Phosphatases
- Phosphorylation
- Protein Phosphatase 1
- Protein Tyrosine Phosphatases
- Temperature
- Vanadates