Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.

doi:10.1093/oxfordjournals.jbchem.a021397

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Article

Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.

Journal of biochemistry - 1 Jul 1996

Azuma Y, Seino H, Seki T, Uzawa S, Klebe C, Ohba T, Wittinghofer A, Hayashi N, Nishimoto T

Abstract excerpt

Charged amino acid residues of human RCC1 were converted to alanine and mutants which were unable to complement tsBN2 cells (a temperature-sensitive rcc1- mutant of the hamster BHK21 cell line) were selected. These RCC1 mutants were analyzed for the ability to inhibit premature chromatin condensa...

Topics

Alanine
Amino Acid Sequence
Animals
Cell Cycle Proteins
Cell Line
Chromatin
Cricetinae
DNA-Binding Proteins
Genetic Complementation Test
Guanine Nucleotide Exchange Factors
Guanine Nucleotides
Histidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kidney

Kinetics

Mesocricetus

Microinjections

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8864848
DOI: 10.1093/oxfordjournals.jbchem.a021397

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8864848-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.PMID 8864848Read ↗

Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene.Semantic proximity Read ↗

Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.Semantic proximity Read ↗

Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.Semantic proximity Read ↗

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.Semantic proximity Read ↗

RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

RCC1 and nuclear organization.Semantic proximity Read ↗

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.Semantic proximity Read ↗

tsBN75 and tsBN423, temperature-sensitive x-linked mutants of the BHK21 cell line, can be complemented by the ubiquitin-activating enzyme E1 cDNA.Semantic proximity Read ↗

RCC1, a regulator of mitosis, is essential for DNA replication.Semantic proximity Read ↗

Steady state fluorescence studies of wild type recombinant cinnamoyl CoA reductase (Ll-CCRH1) and its active site mutants.Semantic proximity Read ↗

The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.Semantic proximity Read ↗

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