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Article

Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.

Journal of biochemistry - 1 Jul 1996

Azuma Y, Seino H, Seki T, Uzawa S, Klebe C, Ohba T, Wittinghofer A, Hayashi N, Nishimoto T

Abstract excerpt

Charged amino acid residues of human RCC1 were converted to alanine and mutants which were unable to complement tsBN2 cells (a temperature-sensitive rcc1- mutant of the hamster BHK21 cell line) were selected. These RCC1 mutants were analyzed for the ability to inhibit premature chromatin condensation by microinjection into tsBN2 cells, and their steady-state kinetic parameters for guanine nucleotide exchange...

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Source

Identifiers

PMID: 8864848
DOI: 10.1093/oxfordjournals.jbchem.a021397

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.PMID 8864848Read ↗

Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene.Semantic proximity Read ↗

Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae.Semantic proximity Read ↗

Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.Semantic proximity Read ↗

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.Semantic proximity Read ↗

RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.Semantic proximity Read ↗

The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.Semantic proximity Read ↗

RCC1 and nuclear organization.Semantic proximity Read ↗

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.Semantic proximity Read ↗

tsBN75 and tsBN423, temperature-sensitive x-linked mutants of the BHK21 cell line, can be complemented by the ubiquitin-activating enzyme E1 cDNA.Semantic proximity Read ↗

RCC1, a regulator of mitosis, is essential for DNA replication.Semantic proximity Read ↗

The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.Semantic proximity Read ↗

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