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Article

The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.

Oncogene - 6 Apr 2006

Bian D, Mahanivong C, Yu J, Frisch S M, Pan Z K, Ye R D, Huang S

Abstract excerpt

The membrane redistribution and phosphorylation of focal adhesion kinase (FAK) have been reported to be important for cell migration. We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. We...

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Identifiers

PMID: 16301993
DOI: 10.1038/sj.onc.1209261

Genes

LPA

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The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.PMID 16301993Read ↗

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