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Article

Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.

International journal of oncology - 1 Oct 2003

Kusama Toshiyuki, Mukai Mutsuko, Ayaki Masako, Imamura Fumio, Tatsuta Masaharu, Matsumoto Yoshirou, Nakamura Hiroyuki, Inoue Masahiro

Abstract excerpt

The mevalonate metabolic pathway is necessary for the isoprenylation of a number of small GTPases. We have previously presented that Rho plays a pivotal role in 1-oleoyl-lysophosphatidic acid (LPA)-induced invasion of rat ascites hepatoma MM1 cells. Herein we report the effect of HMG-CoA reductas...

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Source

Identifiers

PMID: 12964001

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12964001-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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