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Article

Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells.

European journal of pharmacology - 5 Dec 2011

Leve Fernanda, Marcondes Taline Guimarães Corrêa, Bastos Lilian Gonçalves R, Rabello Sarah Vieira, Tanaka Marcelo Neves, Morgado-Díaz José Andrés

Abstract excerpt

Lysophosphatidic acid (LPA) acts as a potent stimulator of tumorigenesis. Cell-cell adhesion disassembly, actin cytoskeletal alterations, and increased migratory potential are initial steps of colorectal cancer progression. However, the role that LPA plays in these events in this cancer type is still unknown. We explored this question by using Caco-2 cells, as colon cancer model, and treatment with LPA or...

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Source

Identifiers

PMID: 21968138
DOI: 10.1016/j.ejphar.2011.09.006

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells.PMID 21968138Read ↗

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