Estimating selection on nonsynonymous mutations.

Abstract excerpt

The distribution of mutational effects on fitness is of fundamental importance for many aspects of evolution. We develop two methods for characterizing the fitness effects of deleterious, nonsynonymous mutations, using polymorphism data from two related species. These methods also provide estimates of the proportion of amino acid substitutions that are selectively favorable, when combined with data on...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drosophila
• Share to Genetics, Population
• Share to Models, Genetic